Pregnancy Bridge Program for Psychiatric Patients

The National Institute of Mental Health (2017) estimates that 9.2 million people age 18 years and older are diagnosed with bipolar disorder in the United States. Research has shown pregnancies in women with mental health problems have higher rates of poor outcomes and complications (Epstein et al., 2014; Freeman, 2007; Rusner et al., 2016; Scrandis, 2017). Aim. The purpose of this scholarly project is to provide standardized patient education, increase urine human chorionic gonadotropin screening rates, and to set up a gynecologic care bridge for patients considering pregnancy and are diagnosed with bipolar disorder. Evidence. The Centers for Disease Control and Prevention (2019b) estimates 51% of pregnancies are unplanned and recommends planning for pregnancy ahead of time. The American College of Obstetricians and Gynecologists (2019) recommends a multidisciplinary care team for patients that plan on pregnancy. Mood-stabilizing and anti-psychotic medications are known human teratogens (Bodén et al., 2012; Mittal et al., 2015; Stahl, 2017). Method. Female patients with bipolar disorder, ages 18-65 years, received standardized medication and contraception education. These patients were screened for pregnancy intentions or human chorionic gonadotropin. Patients that met criteria were connected with a gynecologic provider. Results. 158 patients were screened for pregnancy and offered education over ten weeks. 37 patients had recent pregnancy tests. 50 patients were indicated for follow up. Implications. Medication safety is of paramount importance for this high-risk population. Data captured during this project provides a snapshot. This process should be continuous and championed by health care organizations

Granger causality analysis in neuroscience and neuroimaging

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A normative assessment of the legal philosophy of the european union using the grundnorm theory of hans kelsen

This thesis assesses the normative basis of the law of the European Union according to selected theories of legal and ethical philosophy. Firstly it employs the methodology of legal theorist Hans Kelsen, who envisioned a legal order as a hierarchy of norms with a central norm or Grundnorm at the peak of this hierarchy. Ten such norms are identified within the EU Treaties and related documents, and encompass values such as the ‘promotion of peace’, the ‘rule of law’ and ‘democracy’. However, an examination of the jurisprudential approach of the Court of Justice, which occupies a prominent place in the constitutional law of the EU legal order alongside the Treaties, suggests that the Grundnorm of the EU law is of a functional nature, and is chiefly concerned with the establishment and maintenance of the European Common Market. An assessment of this Grundnorm using the contrasting ethical theories of Kantianism and utilitarianism suggests that the legal philosophy of the European Union is thus consequentially ethical, as the European Common Market brings many benefits, but it is not primarily governed by the protection of deontological values, with these values consistently subordinated to the Common Market Grundnorm. It is then suggested that the functional basis of this Grundnorm will create problems for the ethical legitimacy of the EU legal order in the longer term; it has been constructed in this way by the Court of Justice due to the identity crisis of the Community as caused by the on-going democratic deficit. Thus an ideal Grundnorm for the EU legal system should have a core basis in ethical values, especially those relating to democracy, human rights and the rule of law.http://www.ester.ee/record=b446226

[Letter] Misunderstandings regarding the application of Granger causality in neuroscience

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Solved problems for Granger causality in neuroscience: a response to Stokes and Purdon

Granger-Geweke causality (GGC) is a powerful and popular method for identifying directed functional (‘causal’) connectivity in neuroscience. In a recent paper, Stokes and Purdon (2017b) raise several concerns about its use. They make two primary claims: (1) that GGC estimates may be severely biased or of high variance, and (2) that GGC fails to reveal the full structural/causal mechanisms of a system. However, these claims rest, respectively, on an incomplete evaluation of the literature, and a misconception about what GGC can be said to measure. Here we explain how existing approaches resolve the first issue, and discuss the frequently-misunderstood distinction between functional and effective neural connectivity which underlies Stokes and Purdon's second claim

Topology based global crowd control

We propose a method to determine the flow of large crowds of agents in a scene such that it is filled to its capacity with a coordinated, dynamically moving crowd. Our approach provides a focus on cooperative control across the entire crowd. This is done with a view to providing a method which animators can use to easily populate and fill a scene. We solve this global planning problem by first finding the topology of the scene using a Reeb graph, which is computed from a Harmonic field of the environment. The Maximum flow can then be calculated across this graph detailing how the agents should move through the space. This information is converted back from the topological level to the geometric using a route planner and the Harmonic field. We provide evidence of the system’s effectiveness in creating dynamic motion through comparison to a recent method. We also demonstrate how this system allows the crowd to be controlled globally with a couple of simple intuitive controls and how it can be useful for the purpose of designing buildings and providing control in team sports

What Darwin could not see: island formation and historical sea levels shape genetic divergence and island biogeography in a coastal marine species

Oceanic islands play a central role in the study of evolution and island biogeography. The Galapagos Islands are one of the most studied oceanic archipelagos but research has almost exclusively focused on terrestrial organisms compared to marine species. Here we used the Galapagos bullhead shark (Heterodontus quoyi) and single nucleotide polymorphisms (SNPs) to examine evolutionary processes and their consequences for genetic divergence and island biogeography in a shallow-water marine species without larval dispersal. The sequential separation of individual islands from a central island cluster gradually established different ocean depths between islands that pose barriers to dispersal in H. quoyi. Isolation by resistance analysis suggested that ocean bathymetry and historical sea level fluctuations modified genetic connectivity. These processes resulted in at least three genetic clusters that exhibit low genetic diversity and effective population sizes that scale with island size and the level of geographic isolation. Our results exemplify that island formation and climatic cycles shape genetic divergence and biogeography of coastal marine organisms with limited dispersal comparable to terrestrial taxa. Because similar scenarios exist in oceanic islands around the globe our research provides a new perspective on marine evolution and biogeography with implications for the conservation of island biodiversity

Residency and Spatial Use by Reef Sharks of an Isolated Seamount and Its Implications for Conservation

Although marine protected areas (MPAs) are a common conservation strategy, these areas are often designed with little prior knowledge of the spatial behaviour of the species they are designed to protect. Currently, the Coral Sea area and its seamounts (north-east Australia) are under review to determine if MPAs are warranted. The protection of sharks at these seamounts should be an integral component of conservation plans. Therefore, knowledge on the spatial ecology of sharks at the Coral Sea seamounts is essential for the appropriate implementation of management and conservation plans. Acoustic telemetry was used to determine residency, site fidelity and spatial use of three shark species at Osprey Reef: whitetip reef sharks Triaenodon obesus, grey reef sharks Carcharhinus amblyrhynchos and silvertip sharks Carcharhinus albimarginatus. Most individuals showed year round residency at Osprey Reef, although five of the 49 individuals tagged moved to the neighbouring Shark Reef (∼14 km away) and one grey reef shark completed a round trip of ∼250 km to the Great Barrier Reef. Additionally, individuals of white tip and grey reef sharks showed strong site fidelity to the areas they were tagged, and there was low spatial overlap between groups of sharks tagged at different locations. Spatial use at Osprey Reef by adult sharks is generally restricted to the north-west corner. The high residency and limited spatial use of Osprey Reef suggests that reef sharks would be highly vulnerable to targeted fishing pressure and that MPAs incorporating no-take of sharks would be effective in protecting reef shark populations at Osprey and Shark Reef